Estriol 0.01% Cream

Estriol 0.01% Cream can be prescribed for vaginal problems caused by a lack of the hormone oestrogen, such as vaginal dryness or itching and uncomfortable or painful sexual intercourse.

Healthcare advice

Offer vaginal oestrogen to women with urogenital atrophy (including those on systemic HRT) and continue treatment for as long as needed to relieve symptoms.

Consider vaginal oestrogen for women with urogenital atrophy in whom systemic HRT is contraindicated, after seeking advice from a healthcare professional with expertise in menopause.

If vaginal oestrogen does not relieve symptoms of urogenital atrophy, consider increasing the dose after seeking advice from a healthcare professional with expertise in menopause.

Explain to women with urogenital atrophy that:

  • Symptoms often come back when treatment is stopped
  • Adverse effects from vaginal oestrogen are very rare
  • They should report unscheduled vaginal bleeding to their GP

Do not offer routine monitoring of endometrial thickness during treatment for urogenital atrophy.

How to apply Estriol 0.01% Cream

  • 1
    Remove the cap from the tube. Use the top of the cap to pierce the metal seal on the tube.
  • 2
    One end of the applicator has a plunger, screw the other end of the applicator onto the tube.
  • 3
    Squeeze the tube so that the applicator barrel is completely filled with cream. This will pull the plunger out.
  • 4
    Unscrew the filled applicator and replace the cap on the tube.
  • 5
    Lie down with your knees bent and spread apart.
  • 6
    Gently insert the open end of the applicator well into your vagina.
  • 7
    Push the plunger firmly but gently. Empty the cream into your vagina by pushing the plunger as far as it will go.
  • 8
    Keep the plunger firmly pressed down. Grip the applicator by the barrel and remove the empty applicator.
  • 9
    Wash your hands afterwards.
  • 10
    Use a sanitary towel to stop your clothes getting stained.
  • Note: Estriol 0.01% Cream contains peanut oil.